Phenotype Image Detail

Image

Caption

Deleting Ctsk in hematopoietic cells and osteoclasts increases cancellous bone mass. uCT and x-ray images of femurs from controls (Ctrl) and Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 (cKO Mx1) and Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0 (cKO CD11b) mice at 9 weeks of age.

Copyright

This image is from Lotinun S, J Clin Invest 2013 Jan 16;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194492

Associated Alleles

Symbol	Name
Ctsk^tm1.1Rbar	cathepsin K; targeted mutation 1.1, Roland Baron
Tg(Itgam-cre)AJva	transgene insertion A, Jean Vacher
Tg(Mx1-cre)1Cgn	transgene insertion 1, University of Cologne

Associated Genotypes

Allelic Composition	Genetic Background
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0	involves: C57BL/6
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA