Phenotype Image Detail

Image

Caption

TRAP-positive osteoclast number per area (/mm²) from coculture of either Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar (Ctsk^fl/fl) or Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 (Mx1;Ctsk^fl/fl) osteoblasts with Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar bone marrow macrophages. Greater numbers of TRAP-positive osteoclasts form in coculture of Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 osteoblasts with Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar bone marrow macrophges. Results are mean +/- SEM. *P < 0.05 versus controls.

Copyright

This image is from Lotinun S, J Clin Invest 2013 Jan 16;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194492

Associated Alleles

Symbol	Name
Ctsk^tm1.1Rbar	cathepsin K; targeted mutation 1.1, Roland Baron

Associated Genotypes

Allelic Composition	Genetic Background
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA