Phenotype Image Detail

Image

Caption

uCT images of cortical bone in three conditional knockouts: Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 (cKO Mx1), Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0 (cKO CD11b), and Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (cKO Osx) and their controls (Ctrl). Deletion of Ctsk in osteoclasts (Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0) increases total cross-sectional volume (1.20 +/- 0.05 vs 1.40 +/- 0.06, p<0.05) and cortical bone volume (0.50+/- 0.03 vs 0.65+/-0.05, p<0.05).

Copyright

This image is from Lotinun S, J Clin Invest 2013 Jan 16;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194492

Associated Alleles

Symbol	Name
Ctsk^tm1.1Rbar	cathepsin K; targeted mutation 1.1, Roland Baron
Tg(Itgam-cre)AJva	transgene insertion A, Jean Vacher
Tg(Mx1-cre)1Cgn	transgene insertion 1, University of Cologne
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc	transgene insertion 1, Andrew P McMahon

Associated Genotypes

Allelic Composition	Genetic Background
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0	involves: C57BL/6
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: CD-1