Phenotype Image Detail

Image

Caption

Rod reprogramming prevents retinal degeneration in Rho^tm1Jlem/Rho^tm1Jlem Nrl^tm1Jcco/Nrl^tm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice. Control is Rho^tm1Jlem/Rho^tm1Jlem Nrl^tm1Jcco/Nrl⁺ Tg(CAG-cre/Esr1*)5Amc/0 + 4-OHT and acute Nrl KO is Rho^tm1Jlem/Rho^tm1Jlem Nrl^tm1Jcco/Nrl^tm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 + 4-OHT. (B) H&E and antibody staining show increased preservation of the outer nuclear layer (ONL) and cone opsin expression in Rho^tm1Jlem/Rho^tm1Jlem Nrl^tm1Jcco/Nrl^tm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice relative to controls. (Scale bar, 50 um.)

Copyright

This image is from Montana CL, Proc Natl Acad Sci U S A 2013 Jan 29;110(5):1732-7. Copyright 2013 National Academy of Sciences, U.S.A. J:193697

Associated Alleles

Symbol	Name
Nrl^tm1Jcco	neural retina leucine zipper gene; targeted mutation 1, Joseph C Corbo
Rho^tm1Jlem	rhodopsin; targeted mutation 1, Janis Lem
Tg(CAG-cre/Esr1*)5Amc	transgene insertion 5, Andrew P McMahon

Associated Genotypes

Allelic Composition	Genetic Background
Nrl^tm1Jcco/Nrl^tm1Jcco Rho^tm1Jlem/Rho^tm1Jlem Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S4/SvJae * C57BL/6 * CBA