Phenotype Image Detail

Image

Caption

ABHD12 disruption causes age-dependent increases in microglial activation in the mouse brain. (A-C) Representative images of Iba1 immunostaining for microglia in the cerebellum of 18-month-old (A), 12-month-old (B), and 6-month-old (C) wild-type (ABHD12+/+) and Abhd12^tm1Crv/Abhd12^tm1Crv (ABHD12-/-) mice. (D-F) Quantifying the number of enlarged cells (>200 um²) revealed significantly more activated microglia in cerebellar sections from 18-month-old (D) and 12-month-old (E) mutant mice compared with wild-type mice. No genotype differences were observed at 6 months of age (F). Data represent the averages +/- SEM. ***P < 0.001 (n = 3-4 per genotype per age group). (Scale bar, 100 um.)

Copyright

This image is from Blankman JL, Proc Natl Acad Sci U S A 2013 Jan 22;110(4):1500-5. Copyright 2013 National Academy of Sciences, U.S.A. J:193716

Associated Alleles

Symbol	Name
Abhd12^tm1Crv	abhydrolase domain containing 12; targeted mutation 1, Benjamin F Cravatt

Associated Genotypes

Allelic Composition	Genetic Background
Abhd12^tm1Crv/Abhd12^tm1Crv	involves: C57BL/6