Phenotype Image Detail

Image

Caption

Scanning electron micrographs of cochlear sensory epithelium from Myo7a mutant strains at 8 weeks old. (A-C) Wild-type (Myo7a+/+), (D-F) Myo7a^ewaso/Myo7a^ewaso (Myo7a^I487N/I487N) and (G-I) Myo7a^dmbo2/Myo7a^dmbo2 (Myo7a^F947I/F947I) mice at the apical, middle and basal cochlear level. Signs of degeneration and/or misorientation of outer hair cell (OHC) bundles is evident in both Myo7a^ewaso/Myo7a^ewaso (D-F) and Myo7a^dmbo2/Myo7a^dmbo2 (G-I) mice at all levels of the cochlea. This appears to be more severe in Myo7a^ewaso/Myo7a^ewaso mutants, where many bundles are missing in the mid and basal regions (E and F). Inner hair cell (IHC) bundles are also affected, appearing disorganised and/or showing signs of fusion in the basal levels of Myo7a^ewaso/Myo7a^ewaso cochleae (asterisk in F), and conversely in the apical region of Myo7a^dmbo2/Myo7a^dmbo2 mutants (asterisk in G). Scale bar: 10 um (A-I).

Copyright

This image is from Miller KA, PLoS One 2012;7(12):e51284, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195666

Associated Alleles

Symbol	Name
Myo7a^dmbo2	myosin VIIA; dumbo2
Myo7a^ewaso	myosin VIIA; ewaso

Associated Genotypes

Allelic Composition	Genetic Background
Myo7a^ewaso/Myo7a^ewaso	involves: C57BL/6J
Myo7a^dmbo2/Myo7a^dmbo2	involves: C57BL/6J