Phenotype Image Detail

Image

Caption

Fusion of lumbar vertebrae in Gnai3^tm1Lbi/Gnai3^tm1Lbi mice. (A) B6129F2 wild-type (B6129-Gnai3+/+), 5-day-old, showing wild-type morphology of the second through fifth lumbar vertebrae. (B) Gnai3^tm1Lbi/Gnai3^tm1Lbi 4-day-old on a 129S/SvEv background (129-Gnai3-/-), with partial fusion of the third and fourth lumbar vertebrae. (C) Gnai3^tm1Lbi/Gnai3^tm1Lbi 5-day-old on a C57BL/6 and 129S/SvEv background (B6129-Gnai3-/-), with fusion of the second, third, fourth, and fifth lumbar vertebrae. The fusion of the third and fourth vertebrae is more extensive than that seen in any Gnai3^tm1Lbi/Gnai3^tm1Lbi mouse on the 129S/SvEv background. (Magnification: 10X.)

Copyright

This image is from Plummer NW, Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21366-71. Copyright 2012 National Academy of Sciences, U.S.A. J:193170

Associated Alleles

Symbol	Name
Gnai3^tm1Lbi	G protein subunit alpha i3; targeted mutation 1, Lutz Birnbaumer

Associated Genotypes

Allelic Composition	Genetic Background
Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv * C57BL/6
Gnai3^tm1Lbi/Gnai3^tm1Lbi	involves: 129S/SvEv