Phenotype Image Detail

Image

Caption

Rib fusion phenotype of Gnai3^tm1Lbi/Gnai3^tm1Lbi (Gnai3^-/-) mice is enhanced by loss of Gnai2 in cartilage. (B) Gnai3^tm1Lbi/Gnai3^tm1Lbi Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi (Gnai3-/- Gnai2^flx/flx) neonate with one rib fusion (black arrowhead). (C) Gnai3^tm1Lbi/Gnai3^tm1Lbi Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Tg(Myog-cre)1Eno/0 (Gnai3-/- Gnai2^flx/flx Myog-cre) neonate with one rib fusion (black arrowhead). (D) Gnai3^tm1Lbi/Gnai3^tm1Lbi Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Sox9^tm3(cre)Crm/Sox9⁺ (Gnai3-/- Gnai2^flx/flx Sox9^cre) neonate with 10 rib fusions.

Copyright

This image is from Plummer NW, Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21366-71. Copyright 2012 National Academy of Sciences, U.S.A. J:193170

Associated Alleles

Symbol	Name
Gnai2^tm2.1Lbi	G protein subunit alpha i2; targeted mutation 2.1, Lutz Birnbaumer
Gnai3^tm1Lbi	G protein subunit alpha i3; targeted mutation 1, Lutz Birnbaumer
Sox9^tm3(cre)Crm	SRY (sex determining region Y)-box 9; targeted mutation 3, Benoit de Crombrugghe
Tg(Myog-cre)1Eno	transgene insertion 1, Eric N Olson

Associated Genotypes

Allelic Composition	Genetic Background
Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Gnai3^tm1Lbi/Gnai3^tm1Lbi Sox9^tm3(cre)Crm/Sox9^+	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Gnai2^tm2.1Lbi/Gnai2^tm2.1Lbi Gnai3^tm1Lbi/Gnai3^tm1Lbi Tg(Myog-cre)1Eno/0	involves: 129S/SvEv * C57BL/6