Phenotype Image Detail

Image

Caption

Loss of Krt7 is associated with hyperproliferation but not hyperplasia of the bladder urothelium. Immunohistochemistry of bladder sections from wild-type (A, D), heterozygous (B, E) and homozygous Krt7^tm1Whim mice (C, F) stained with a rabbit polyclonal antibody to Krt7 (A, B, C) and mouse monoclonal antibody MM1 to the cell proliferation marker Ki-67 (D, E, F). Arrowheads and insets in panels D and E indicate Ki-67 positive nuclei in wild-type (D) and heterozygous (E) bladder. More Ki-67 positive cell nuclei can be seen in the bladder of Krt7^tm1Whim/Krt7^tm1Whim (KO) mice (arrowheads in F). Scale bars = 50 um.

Copyright

This image is from Sandilands A, PLoS ONE 2013;8(5):e64404, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:196575

Associated Alleles

Symbol	Name
Krt7^tm1Whim	keratin 7; targeted mutation 1, William Henry Irwin McLean

Associated Genotypes

Allelic Composition	Genetic Background
Krt7^tm1Whim/Krt7^tm1Whim	involves: 129P2/OlaHsd * C57BL/6