Phenotype Image Detail

Image

Caption

Gastric histology. A, corpus and antrum of wild-type (AGR2 WT) mice at 16 weeks and Agr2^tm1.1Lex/Agr2^tm1.1Lex (AGR2 KO) mice at 6 and 16 weeks are shown. The brackets at 6 weeks mark the expanding zone of clear cells in the antrum above the lamina propria. B, shown is high magnification of the corpus gland base containing chief and parietal cells in wild-type and mutant mice. Representative parietal cells are marked with asterisks, and chief cells are marked with arrowheads. C, high magnification of the antral gland base is shown. Progressive mucosal hyperplasia is seen in the corpus and antrum of mutants. The black scale bars represent 50 um.

Copyright

This image is from Gupta A, J Biol Chem 2013 Feb 8;288(6):4321-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:195573

Associated Alleles

Symbol	Name
Agr2^tm1.1Lex	anterior gradient 2; targeted mutation 1.1, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Agr2^tm1.1Lex/Agr2^tm1.1Lex	involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6