Phenotype Image Detail

Image

Caption

Bub1 kinase activity is required for chromosome alignment and maintenance of chromosomal stability.Representative images for chromosome segregation defects in Bub1^tm3.1Jvd/Bub1^tm3.1Jvd mouse embryo fibroblasts (MEFs) by live-cell imaging. White arrowheads shows misaligned chromosomes. Bar, 10 um.

Copyright

This image is from Ricke RM, J Cell Biol 2012 Dec 10;199(6):931-49, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:195237

Associated Alleles

Symbol	Name
Bub1^tm3.1Jvd	BUB1, mitotic checkpoint serine/threonine kinase; targeted mutation 3.1, Jan M A van Deursen

Associated Genotypes

Allelic Composition	Genetic Background
Bub1^tm3.1Jvd/Bub1^tm3.1Jvd	involves: 129S4/SvJae * C57BL/6