Phenotype Image Detail

Image

Caption

Smg1^{Gt(AG0297)Wtsi}/Smg1⁺ mice have decreased viability compared with wild-type (WT) littermates. (A) Kaplan-Meier survival plot shows the significantly decreased viability of heterozygous mutant mice compared with WT littermates. Statistical significance was determined using Prism 5 software (GraphPad Software). H&E staining of paraffin-embedded sections shows key pathological findings observed in heterozygous mice [lymphomas (B), chronic inflammation (C), papillary adenocarcinoma (D), and steatosis (E)] and WT tissues for comparison [lung (F), spleen (G), and liver (H)].

Copyright

This image is from Roberts TL, Proc Natl Acad Sci U S A 2013 Jan 22;110(4):E285-94. Copyright 2013 National Academy of Sciences, U.S.A. J:193626

Associated Alleles

Symbol	Name
Smg1^Gt(AG0297)Wtsi	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; gene trap AG0297, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Smg1^Gt(AG0297)Wtsi/Smg1^+	involves: 129P2/OlaHsd * C57BL/6