Phenotype Image Detail

Image

Caption

Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ (Cd28-deltaTreg) mice develop autoimmunity with skin inflammation. (A) Gross appearance and lymph nodes and spleens from representative wild-type littermate control (labeled 1 and 3) and mutant (labeled 2 and 4) mice.

Copyright

This image is from Zhang R, J Clin Invest 2013 Jan 2;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194503

Associated Alleles

Symbol	Name
Cd28^tm1Ltu	CD28 antigen; targeted mutation 1, Laurence A Turka
Foxp3^tm4(YFP/icre)Ayr	forkhead box P3; targeted mutation 4, Alexander Y Rudensky

Associated Genotypes

Allelic Composition	Genetic Background
Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^tm4(YFP/icre)Ayr/Foxp3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6