Phenotype Image Detail

Image

Caption

Histologic analysis. (A and B) H&E staining of (A) livers, kidneys, and pancreata or (B) intestines and colons in 3-month-old Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ (Cd28^fl/fl x Foxp3^YFP-Cre) mice. Histological analysis showed scattered foci of mononuclear cells in liver, pancreas, kidney, intestine, and colon. Original magnification, X400 (A and B). Data are representative of at least 3 animals.

Copyright

This image is from Zhang R, J Clin Invest 2013 Jan 2;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194503

Associated Alleles

Symbol	Name
Cd28^tm1Ltu	CD28 antigen; targeted mutation 1, Laurence A Turka
Foxp3^tm4(YFP/icre)Ayr	forkhead box P3; targeted mutation 4, Alexander Y Rudensky

Associated Genotypes

Allelic Composition	Genetic Background
Cd28^tm1Ltu/Cd28^tm1Ltu Foxp3^tm4(YFP/icre)Ayr/Foxp3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6