Phenotype Image Detail

Image

Caption

Urothelial hyperplasia with increased BrdU incorporation in Cldn4^tm1.1Yham/Cldn4^tm1.1Yham (Cldn4^-/-) mice. (A) Sections of the uretero-pelvic junction regions (left panels) and lower part of the ureters (right panels) of heterozygous and homozygous littermate mice (8-19 month old) with no evidence of hydronephrosis were stained with hematoxylin and eosin. Dotted lines indicate the urothelial basal layers. Note the increased urothelial cell numbers and layers. Bars, 50 um. (B) Heterozygous and homozygous littermate mice (12 months old) were injected with BrdU (1 mg/animal) intraperitoneally for 4 consecutive days, and the sections of the ureters (left) and bladders (right) were three-color immunostained with anti-BrdU (green, arrows), anti-keratin (red), and DAPI (blue). Bars, 50 um.

Copyright

This image is from Fujita H, PLoS One 2012;7(12):e52272, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:195766

Associated Alleles

Symbol	Name
Cldn4^tm1.1Yham	claudin 4; targeted mutation 1.1, Yoko Hamazaki

Associated Genotypes

Allelic Composition	Genetic Background
Cldn4^tm1.1Yham/Cldn4^tm1.1Yham	B6.129S2-Cldn4^tm1.1Yham