Phenotype Image Detail

Image

Caption

Abnormal morphology and migration of Slc4a2^tm1Ges/Slc4a2^tm1Ges (Slc4a2-/-) osteoclasts. (A) Confocal images of F-actin (red) and nuclei (blue) in osteoclast-like cells (OCLs). (Scale bars, 100 um.) (B) Distance moved (means +/- SE) over 5 hours by OCLs (**P < 0.005). (C and D) Transmission electron microscopy (C) and confocal images (D) of osteoclasts at the proximal tibial growth plate from 5-day-old mice. (C) Bone (B), ruffled border (RB), osteoclast (OC), and sealing zone (SZ). (Scale bars, 2 um.) (D) F-actin (red), V-ATPase B2 subunit (green), nuclei (blue) and sealing zones (asterisks). (Scale bars, 5 um.)

Copyright

This image is from Coury F, Proc Natl Acad Sci U S A 2013 Feb 5;110(6):2163-8. Copyright 2013 National Academy of Sciences, U.S.A. J:193823

Associated Alleles

Symbol	Name
Slc4a2^tm1Ges	solute carrier family 4 (anion exchanger), member 2; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Slc4a2^tm1Ges/Slc4a2^tm1Ges	involves: 129S6/SvEvTac