Phenotype Image Detail

Image

Caption

Histology of Pkd1^tm1.1Pcha/Pkd1^tm1Shh (Pkd1^RC/del2) mice highlights early-onset and rapidly progressive cystic disease. Representative Masson Trichrome sections of mutant and wild-type (WT) kidneys from E14.5 to P180 Kidney cysts were clearly visible as early as E16.5 (a few cysts were present at E15.5) and rapidly increased in number/size with age. Glomerular cysts were present as early as E16.5 (insets). The kidneys of animals with longer survival (P180) were highly fibrotic, with little obvious healthy tissue. Scale bars: 100 um (E14.5 to P1); 500 um (P12); 750 um (P25 and P180); 50 um (insets).

Copyright

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Pkd1^tm1Shh	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1Shh/Pkd1^tm1.1Pcha	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6