Phenotype Image Detail

Image

Caption

Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha (Pkd1^RC/RC) and Pkd1^tm1.1Pcha/Pkd1^tm1Shh (Pkd1^RC/del2) mice show a switch in tubular cyst origin (from proximal tubule to collecting duct) corresponding to age. (A) IF lectin labeling of proximal tubule (PT) (LTA) and collecting duct (CD) (DBA). During early kidney development (P1), cysts originated mainly from PT in Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha and Pkd1^tm1.1Pcha/Pkd1^tm1Shh animals, with only rare CD cysts (arrowheads). Later in development (P12), a switch to more CD cysts occurred that became more prominent after kidney development (P25, Pkd1^tm1.1Pcha/Pkd1^tm1Shh; 3 months, Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha), with only a few remaining PT cysts (arrows). With disease progression, an increasing number of cysts seemed to dedifferentiate. Asterisks indicate a lack of labeling with tubule markers. Scale bars: 100 um (P1); 200 um (P12); 300 um (P25); 500 um (3 months and 12 months).

Copyright

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Pkd1^tm1Shh	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha	involves: 129S1/Sv * C57BL/6
Pkd1^tm1Shh/Pkd1^tm1.1Pcha	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6