Phenotype Image Detail

Image

Caption

Cyst development during embryogenesis and the first postnatal month in Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha (Pkd1^RC/RC) and Pkd1^tm1.1Pcha/Pkd1^tm1Shh (Pkd1^RC/del2) animals. During embryonic development, kidney cysts (*) are detectable in Pkd1^tm1.1Pcha/Pkd1^tm1Shh mutant mice by E15.5 and Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha mutant mice by E16.5. Subsequently, cystogenesis proceeded much more rapidly in Pkd1^tm1.1Pcha/Pkd1^tm1Shh versus Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha animals. Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha mice, nonetheless, have a significant cyst burden during renal development and, indeed, have a higher percentage of kidney weight per body weight (%KW/BW) at P15 than at 1 month. This is probably because proximal tube (PT) cysts dominate the cyst burden at the early stages, but then decline as collecting duct (CD) cysts become the major adult disease manifestation. Scale bars: E15.5 = 100 um, E16.6 = 150 um, E18.5 and P1 = 250 um, P15 = 750 um.

Copyright

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Pkd1^tm1Shh	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1.1Pcha/Pkd1^tm1.1Pcha	involves: 129S1/Sv * C57BL/6
Pkd1^tm1Shh/Pkd1^tm1.1Pcha	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6