Phenotype Image Detail

Image

Caption

(A) Pkd1^tm1.1Pcha/Pkd1^tm1Shh (Pkd1^RC/del2) animals develop anosteopenia like phenotype characterized by a significant decrease in cortical (left microCT image + graph) and trabecular (right microCT image) bone mass - a phenotype known to be associated with a reduction of Pkd1 in mice. BV: Bone volume, TV: Tissue volume. Statistical values were obtained by Student t-test (*p<0.05, ***p<0.001); error bars indicate +/- SD.

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated
Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Pkd1^tm1Shh	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie

Associated
Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1Shh/Pkd1^tm1.1Pcha	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

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