Phenotype Image Detail

Image

Caption

(B) Pkd1^tm1.1Pcha/Pkd1^tm1Shh (Pkd1^RC/del2) animals show early signs of left ventricular hypertrophy (LVH). LVH is a known cardiovascular complication in Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients and is often characterized by an increase in heart weight (HW) (right) due to the thickening of the myocardium (left). HW was measured as percent extra renal body weight (ERBW = BW - KW) and myocardium thickness was measured along the free wall (FW) and the left ventricular septum (LVS), n=7/group. Scale bars = 1 mm. No significant accumulation of fibrosis was noted in the LV myocardium of mutant animals, which would indicate cardiac failure. Taken together (A & B), this data suggests that mutant animals likely develop hypertension. Statistical values were obtained by Student t-test (*p<0.05, ***p<0.001); error bars indicate +/- SD.

Copyright

This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544

Associated Alleles

Symbol	Name
Pkd1^tm1.1Pcha	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Peter Harris
Pkd1^tm1Shh	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Shigeo Horie

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1Shh/Pkd1^tm1.1Pcha	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6