Phenotype Image Detail

Image

Caption

Characterization of skin cancers of Mob1a/Mob1b-deficient mice. H&E-stained sections of representative tumors from Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺ (Mob1a^delta/delta Mob1b^tr/+) or Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} (Mob1a^delta/+ Mob1b^tr/Mob1b^tr) mice showing: (top left) characteristic trichilemmal keratinization (yellow arrows; also in right); (bottom left) atypical and highly mitotic cells; and (right) continuity with the epidermis. Scale bars: 50 um (left); 500 um (right).

Copyright

This image is from Nishio M, J Clin Invest 2012 Dec 3;122(12):4505-18 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193981

Associated Alleles

Symbol	Name
Mob1a^tm1.2Asuz	MOB kinase activator 1A; targeted mutation 1.2, Akira Suzuki
Mob1b^Gt(CC0690)Wtsi	MOB kinase activator 1B; gene trap CC0690, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^+	involves: 129P2/OlaHsd * C57BL/6
Mob1a^tm1.2Asuz/Mob1a^+ Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi	involves: 129P2/OlaHsd * C57BL/6