Phenotype Image Detail

Image

Caption

Non-cancerous phenotypes observed in Mob1a/Mob1b mutant mice. Severe (left) and mild (right) dental malocclusion in Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} (Mob1a^delta/+ Mob1b^tr/tr) mice. (B) Immunohistochemical analysis using anti-Myosin-6 Ab to visualize the disorganized hair bundles in the mutant mouse compared to a control (Mob1a^+/+ Mob1b^tr/tr) mouse. Scale bar, 50 um. (C) H&E-stained sections of femoral bone tissue showing an increased number of trabeculae in a mutant mouse compared to a control. Bar, 1000 um.

Copyright

This image is from Nishio M, J Clin Invest 2012 Dec 3;122(12):4505-18 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193981

Associated Alleles

Symbol	Name
Mob1a^tm1.2Asuz	MOB kinase activator 1A; targeted mutation 1.2, Akira Suzuki
Mob1b^Gt(CC0690)Wtsi	MOB kinase activator 1B; gene trap CC0690, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Mob1a^tm1.2Asuz/Mob1a^+ Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi	involves: 129P2/OlaHsd * C57BL/6