Phenotype Image Detail

Image

Caption

Kif7 is a negative regulator of cell proliferation in the primordial diaphragm. (A and B) Wilms tumor-1 (Wt1) and (C and D) cyclin D1 (Ccnd1) immunofluorescent staining (red) in sagittal sections of E12.5 wild-type (WT) and Kif7^dda/Kif7^dda (Kif7^dd/dd) embryos. (E) Comparison of relative frequency of numbers of Wt1+ cells, Wt1+/BrdU+ nonmesothelial mesenchymal cells, Wt1+/BrdU+ mesothelial cells, BrdU+ cells, and Ccnd1+ within the domains marked by the dotted line in A-D in E12.5 WT and mutant diaphragms. Data represent mean relative frequency of cell number, and error bars represent SE; n = 4 independent experiments (*P < 0.05, t test).

Copyright

This image is from Coles GL, Proc Natl Acad Sci U S A 2013 May 21;110(21):E1898-905. Copyright 2013 National Academy of Sciences, U.S.A. J:197449

Associated Alleles

Symbol	Name
Kif7^dda	kinesin family member 7; disorganized diaphragm allele

Associated Genotypes

Allelic Composition	Genetic Background
Kif7^dda/Kif7^dda	FVB.A-Kif7^dda