Phenotype Image Detail

Image

Caption

The Kif7^dda/Kif7^dda (dd) embryos have multiple developmental defects associated with syndromic congenital diaphragmatic hernia. (A and B) Images of whole-mount E17.5 wild-type and mutant diaphragms with description of diaphragm anatomy. (C and D) Images of E14.5 embryos show that mutant embryos have exencephaly (arrowhead). (E and F) Transverse sections stained with H&E shows that E15.5 mutant embryos have ventricular septal defects (arrowhead). (G and H) Skeletal preparations stained with Alcian Blue (cartilage) and Alizarin red (bone) of E18.5 embryos reveal that mutant embryos have defects in rib and sternum development (arrowheads). (I and J) Images of lungs and heart indicate that mutant embryos possess pulmonary hypoplasia (arrowheads) with abnormal cardiac position (arrow).

Copyright

This image is from Coles GL, Proc Natl Acad Sci U S A 2013 May 21;110(21):E1898-905. Copyright 2013 National Academy of Sciences, U.S.A. J:197449

Associated Alleles

Symbol	Name
Kif7^dda	kinesin family member 7; disorganized diaphragm allele

Associated Genotypes

Allelic Composition	Genetic Background
Kif7^dda/Kif7^dda	FVB.A-Kif7^dda