Phenotype Image Detail

Image

Caption

Immunohistochemistry for glial fibrillary acidic protein (GFAP) in spinal anterior horns of control (a-f) and Psmc4^tm1.1Ryot/Psmc4^tm1.2Ryot Tg(SLC18A3-cre)KMisa/0 (Rpt3-CKO) mice (g-l), showing an increase in size and number of reactive astrocytes in anterior horns at 6 weeks of age, which further progressed along with the disease progression (a-f). Control mice demonstrate apparently low levels of astrogliosis (g-l). Scale bars, 10 um.

Copyright

This image is from Tashiro Y, J Biol Chem 2012 Dec 14;287(51):42984-94 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:193770

Associated Alleles

Symbol	Name
Psmc4^tm1.1Ryot	proteasome (prosome, macropain) 26S subunit, ATPase, 4; targeted mutation 1.1, Ryosuke Takahashi
Psmc4^tm1.2Ryot	proteasome (prosome, macropain) 26S subunit, ATPase, 4; targeted mutation 1.2, Ryosuke Takahashi
Tg(SLC18A3-cre)KMisa	transgene insertion K, Hidemi Misawa

Associated Genotypes

Allelic Composition	Genetic Background
Psmc4^tm1.1Ryot/Psmc4^tm1.2Ryot Tg(SLC18A3-cre)KMisa/0	involves: C57BL/6 * C57BL/6N