Phenotype Image Detail

Image

Caption

Development of cysts in pancreas and kidney caused by Col1a1(3.6)-Cre-mediated conditional deletion of Pkd1. Hematoxylin-eosin (H&E) staining (5X) for pancreas (A) and kidney (B) between E14.5 and P14. Both pancreatic duct and renal tubule cysts started at E15.5 in Tg(Col1a1-cre)1Bek/0 Pkd1^tm2Ggg/Pkd1^tm2Ggg (Col1a1(3.6)-Cre;Pkd1^flox/flox) embryos, and the size of renal cystic lesions developed rapidly between E15.5 and P14.

Copyright

This image is from Qiu N, PLoS One 2012;7(9):e46038, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:191967

Associated Alleles

Symbol	Name
Pkd1^tm2Ggg	polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Gregory G Germino
Tg(Col1a1-cre)1Bek	transgene insertion 1, Barbara E Kream

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0	involves: 129S4/SvJae * CD-1