Phenotype Image Detail

Image

Caption

Development of fibrosis in kidney caused by Col1a1(3.6)-Cre-mediated conditional deletion of Pkd1. Masson-Trichrome staining for fibrosis in polycystic kidney sections (A)1X, (B)20X magnification between E16.5 and 8 weeks (8w). Masson-trichrome staining was observed in polycystic kidney tissue at P7 and became more severe at 8 weeks of age, indicating a renal fibrosis formation occurring in Tg(Col1a1-cre)1Bek/0 Pkd1^tm2Ggg/Pkd1^tm2Ggg (Col1a1(3.6)-Cre;Pkd1^flox/flox) mice.

Copyright

This image is from Qiu N, PLoS One 2012;7(9):e46038, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:191967

Associated Alleles

Symbol	Name
Pkd1^tm2Ggg	polycystin 1, transient receptor potential channel interacting; targeted mutation 2, Gregory G Germino
Tg(Col1a1-cre)1Bek	transgene insertion 1, Barbara E Kream

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm2Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0	involves: 129S4/SvJae * CD-1