Phenotype Image Detail

Image

Caption

Gbx1^tm1.1Stwt/Gbx1^tm1.1Stwt (Gbx1^-/-) embryos display abnormal projection of proprioceptive afferents and decrease in peripherin+ ventral motor neurons. Peripherin immunolabeling in lumbar spinal cord sections at E14.5 and E15.5. Arrows indicate proprioceptive afferents extending into the spinal cord. Control (Gbx1^+/-) mice show normal projection of afferents into the intermediate spinal cord (A) and ventral termination zone (C). Many of the proprioceptive afferents fail to project into the ventral spinal cord of homozygous mutant (Gbx1^-/-) mice (B and D). Homozygous mutant embryos also show a marked decrease in the expression of peripherin+ ventral motor neurons (brackets) in (B and D) when compared to control mice (A and C). Scale bars represent 100 mm. 10X magnification.

Copyright

This image is from Buckley DM, PLoS One 2013;8(2):e56214, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:197199

Associated Alleles

Symbol	Name
Gbx1^tm1.1Stwt	gastrulation brain homeobox 1; targeted mutation 1.1, Samuel T Waters

Associated Genotypes

Allelic Composition	Genetic Background
Gbx1^tm1.1Stwt/Gbx1^tm1.1Stwt	involves: C57BL/6 * FVB/N