Phenotype Image Detail

Image

Caption

ISL1+ and ISL1+/peripherin+ co-expressing motor neurons are reduced in Gbx1^tm1.1Stwt/Gbx1^tm1.1Stwt (Gbx1^-/-) ventral spinal cord. Immunohistochemical analysis for ISL1 (A-D) and ISL1+/peripherin+ co-expressing cells (E-H) in lumbar spinal cord sections at E14.5 and E15.5. Expression of ISL1+ motor neurons (A and C) and ISL1+/peripherin+ co-expressing cells (E and G) in the ventral spinal cord of control (Gbx1^+/-) embryos. Homozygous mutant embryos show a significant reduction in the number of ISL1 ventral motor neurons at E14.5 and E15.5 (B and D) and motor neurons coexpressing ISL1/peripherin (F and H). Scale bars represent 100 mm. 20X magnification.

Copyright

This image is from Buckley DM, PLoS One 2013;8(2):e56214, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:197199

Associated Alleles

Symbol	Name
Gbx1^tm1.1Stwt	gastrulation brain homeobox 1; targeted mutation 1.1, Samuel T Waters

Associated Genotypes

Allelic Composition	Genetic Background
Gbx1^tm1.1Stwt/Gbx1^tm1.1Stwt	involves: C57BL/6 * FVB/N