Phenotype Image Detail

Image

Caption

Hydrocephalus in Jam3^tm1Rha/Jam3^tm1Rha C57BL/6 (JAM-C^-/-) mice is accompanied by reactive gliosis. Immunostaining for glial fibrillary acidic protein (GFAP) reveals reactive gliosis in mutant mice. Mutant mice (symptomatic hydrocephalus score 1 shown here) exhibit extensive gliosis in the cortex (C and D) and hippocampus (G and H) as compared to wild-type (WT) littermates (A, B, E and F). In the cerebellum of mutants, only a mild increase of GFAP staining could be observed (K and L) as compared to WT cerebellum (I and J). Bars as indicated.

Copyright

This image is from Wyss L, PLoS One 2012;7(9):e45619, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:191990

Associated Alleles

Symbol	Name
Jam3^tm1Rha	junction adhesion molecule 3; targeted mutation 1, Ralf H Adams

Associated Genotypes

Allelic Composition	Genetic Background
Jam3^tm1Rha/Jam3^tm1Rha	B6.129P2-Jam3^tm1Rha