Phenotype Image Detail

Image

Caption

Hydrocephalus in Jam3^tm1Rha/Jam3^tm1Rha C57BL/6 (JAM-C^-/-) mice is accompanied by loss of cortical layering. Immunostaining for neurofilament (NF) together with Tuj1 reveals loss of cortical layering in mutant mice (hydrocephalus score 1 shown; C and D) when compared to wild-type (WT) littermates (A and B). Inserts in B and D show pyramidal cells. Note that in the mutant mice no axonal and dendritic processes are visible. In contrast, the overall structure of the hippocampus (E and G) and the cerebellum (F and H) of mutant mice did not show any detectable alterations in NF/Tuj1 positive cells when compared to WT littermates. Bars as indicated.

Copyright

This image is from Wyss L, PLoS One 2012;7(9):e45619, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:191990

Associated Alleles

Symbol	Name
Jam3^tm1Rha	junction adhesion molecule 3; targeted mutation 1, Ralf H Adams

Associated Genotypes

Allelic Composition	Genetic Background
Jam3^tm1Rha/Jam3^tm1Rha	B6.129P2-Jam3^tm1Rha