Phenotype Image Detail

Image

Caption

Hydrocephalus in Jam3^tm1Rha/Jam3^tm1Rha (Jam-C^-/-) mice is accompanied by hemorrhages. A: Hematoxylin and eosin staining showing signs of fresh (asterisk) and elder (arrows) bleedings within the III. ventricle. Elder bleedings consisted of erythrophages, hemosiderophages and also haematoidin pigment, the latter indicating bleedings older than 8 days (original magnification: 10X). B: Signs of elder bleedings were also observed within the aqueduct (arrow indicating hemosiderophage; HE stain; original magnification: 40X). C: Fresh and elder hemorrhages were also seen in the perivascular spaces (arrow) and within the central nervous system (CNS) tissue (asterisk) (HE stain; original magnification 10X). D: Iron staining indicating the presence of abundant intraparenchymal iron-loaden macrophages (original magnification: 40X). E, F: Subarachnoidal hemorrhages presenting with areas of fresh (E; arrows; HE staining; original magnification: 10X) and elder bleedings (F; iron staining; original magnification: 40X).

Copyright

This image is from Wyss L, PLoS One 2012;7(9):e45619, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:191990

Associated Alleles

Symbol	Name
Jam3^tm1Rha	junction adhesion molecule 3; targeted mutation 1, Ralf H Adams

Associated Genotypes

Allelic Composition	Genetic Background
Jam3^tm1Rha/Jam3^tm1Rha	B6.129P2-Jam3^tm1Rha