Phenotype Image Detail

Image

Caption

Lateral ventricle DiI injections do not reach the 4th ventricle of Jam3^tm1Rha/Jam3^tm1Rha (JAM-C^-/-) mice with symptomatic hydrocephalus. A. Injection scheme for DiI is shown. B. DiI (red) distribution in the ventricular system in sagittal sections from a C57BL/6 wild-type (WT) and a hydrocephalic mutant mouse is shown. Nuclear staining (DAPI) is shown in blue, unspecific fluorescence in green. LV = lateral ventricle; asterisk = 3rd ventricle; arrows point to 4th ventricle. C-F) DiI distribution within the lateral ventricles. G-J) DiI distribution within the 3rd ventricle. Note that in J (JAM-C^-/- score 1) the 3rd ventricle contains little or no DiI. K-N) DiI distribution within the 4th ventricle. Note that in N (JAM-C^-/- score 1) the 4th ventricle contains no DiI.

Copyright

This image is from Wyss L, PLoS One 2012;7(9):e45619, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:191990

Associated Alleles

Symbol	Name
Jam3^tm1Rha	junction adhesion molecule 3; targeted mutation 1, Ralf H Adams

Associated Genotypes

Allelic Composition	Genetic Background
Jam3^tm1Rha/Jam3^tm1Rha	B6.129P2-Jam3^tm1Rha