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Caption | Abnormal airway capillary coupling. (A and B) IHC for PECAM an endothelial marker, showing defect in capillary formation at E15.5 in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ (Ptenfl/fl;Dermo-Cre) mice. (C and D) Transmission electron microscopy confirmed increased distance (white arrows) between capillaries (red asterisks: blood cells) and alveoli in Ptentm1Hwu/Ptentm1Hwu Twist2tm1.1(cre)Dor/Twist2+ lungs. (E) The airway-capillary distance was significantly thicker in mutant lungs (*P < 0.01, n = 3). Scale bars: 50 um (A and B); 5 um (C and D). | ||||||
Copyright | This image is from Tiozzo C, J Clin Invest 2012 Nov 1;122(11):3862-72 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:192736 | ||||||
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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