Phenotype Image Detail

Image

Caption

Embryonic and perinatal mortality in Pten^tm1Hwu/Pten^tm1Hwu Twist2^{tm1.1(cre)Dor}/Twist2⁺ (Pten^{f/f;Dermo-Cre}) mice due to vascular defects. (A-D) Gross appearance of representative control (A,C) and mutant (B,D) E15.5 (A,B) and E18.5 (C,D) embryos. Note skin pallor in mutants caused vascular failure (B) with hemorrhages at E18.5 (D). (E) Mutant mice (left) at birth with cyanosis.

Copyright

This image is from Tiozzo C, J Clin Invest 2012 Nov 1;122(11):3862-72 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:192736

Associated Alleles

Symbol	Name
Pten^tm1Hwu	phosphatase and tensin homolog; targeted mutation 1, Hong Wu
Twist2^tm1.1(cre)Dor	twist basic helix-loop-helix transcription factor 2; targeted mutation 1.1, David M Ornitz

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm1Hwu/Pten^tm1Hwu Twist2^tm1.1(cre)Dor/Twist2^+	B6.129-Twist2^tm1.1(cre)Dor Pten^tm1Hwu