Phenotype Image Detail

Image

Caption

Comparison of mitochondrial respiratory function in Polg^tm1Jiha/Polg⁺ (+/m, heterozygous mutator mice), Polg^tm1Jiha/Polg^tm1Jiha, (m/m, homozygous mutator mice), and Del(MTmt-Tk-mt-Nd5)1Jiha (Delta, mito-miceDelta) mice. Wild-type (WT). (A) Histochemical analysis of mitochondrial respiratory enzyme activities in the heart and kidney. Tissue sections were stained for cytochrome c oxidase (COX) (brown) and succinate dehydrogenase (SDH) (blue). Cells that had lost COX activity were detected as a blue color. The proportions of DmtDNA in the heart and kidney tissues from mito-miceDelta were 82.6%, and 79.1%, respectively. A scale bar, 50 um.

Copyright

This image is from Mito T, PLoS One 2013;8(2):e55789, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199416

Associated Alleles

Symbol	Name
Del(MTmt-Tk-mt-Nd5)1Jiha	deletion, MT, Jun-Ichi Hayashi 1
Polg^tm1Jiha	polymerase (DNA directed), gamma; targeted mutation 1, Jun-Ichi Hayashi

Associated Genotypes

Allelic Composition	Genetic Background
Polg^tm1Jiha/Polg^tm1Jiha	involves: C57BL/6JJcl
Polg^tm1Jiha/Polg^+	involves: C57BL/6JJcl
Del(MTmt-Tk-mt-Nd5)1Jiha	involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj