Phenotype Image Detail

Image

Caption

Sarcomeric maturation in Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 (Rheb-/-) hearts. A, electron microscopic analysis. At postnatal day 3 or 5, the sarcomere structures in both wild-type and mutant mice were immature, indicated by a narrow sarcomere width. At postnatal day 8, the width of the sarcomere became greater in wild-type mice but it remained narrow in the mutant mice, indicating that sarcomere maturation is impaired. Scale bar, 2.5 um.

Copyright

This image is from Tamai T, J Biol Chem 2013 Apr 5;288(14):10176-87 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:197831

Associated Alleles

Symbol	Name
Rheb^tm1.1Otsu	Ras homolog enriched in brain; targeted mutation 1.1, Kinya Otsu
Tg(Myh6-cre)2182Mds	transgene insertion 2182, Michael D Schneider

Associated Genotypes

Allelic Composition	Genetic Background
Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6J * FVB/N