Phenotype Image Detail

Image

Caption

Morphology of peripheral blood and bone marrow cells from Smap1^tm1.1Sata/Smap1^tm1.1Sata mice. Smear samples were stained by May-Grunwald Giemsa. (A-F) In peripheral blood (PB), the cells are (A) polychromatic erythrocytes (arrows), (B) Howell-Jolly bodies (arrows), (C) erythroblasts (arrows), (D) giant platelets (arrow), (E) micromegakaryocytes (arrow), and (F) hypersegmented neutrophils (arrow). (G-K) In bone marrow cells (BM), the abnormal cells include (G) megaloblasts (arrow) and binucleated basophilic erythroblasts (arrowheads), (H) basophilic erythroblasts with cytoplasmic blebs (arrowheads) and pseudo-Pelger-Huet neutrophils (arrow), (I) multinucleated polychromatic megaloblasts, (J) orthochromatic erythroblasts with fragmented nuclei (arrows), and (K) megakaryocytes with hypolobulated nuclei. Scale bar: 10 um.

Copyright

This image is from Kon S, J Clin Invest 2013 Mar 1;123(3):1123-37 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:196385

Associated Alleles

Symbol	Name
Smap1^tm1.1Sata	small ArfGAP 1; targeted mutation 1.1, Masanobu Satake

Associated Genotypes

Allelic Composition	Genetic Background
Smap1^tm1.1Sata/Smap1^tm1.1Sata	B6.Cg-Smap1^tm1.1Sata