Phenotype Image Detail

Image

Caption

Rere^om/Rere^eyes3 (Rere^om/eyes3) embryos on a C57BL6 background have cardiovascular malformations. Transverse sections of mutant embryos and wild-type (Rere^+/+) littermate controls at E15.5. A-B) A wild-type embryo with a normal left-sided descending aorta (white arrow), a pulmonary artery that emerges from the right ventricle (red arrow), and an ascending aorta that emerges from the left ventricle (yellow arrow). C) A mutant embryo with a right-sided aorta (white arrow) with an aberrant left subclavian artery (not shown) and double outlet right ventricle in which ascending aorta emerges from the right ventricle (yellow arrow). In this embryo, the left pulmonary artery (blue arrow) originates abnormally from the ductus arteriosus. D-F) A mutant embryo with transposition of the great arteries in which the ascending aorta emerges from the right ventricle (yellow arrow) and the ductus arteriosus and left and right pulmonary arteries (blue arrows) emerge from the left ventricle. The red arrow in panel E points to the region of the left ventricle below the valve leading to the pulmonary artery. This embryo also has a periventricular septal defect (black arrow). G-I) A mutant embryo with double outlet right ventricle in which the ascending aorta (yellow arrow) emerges from the right ventricle. This embryo had two separate periventricular septal defects (black arrows in panel H and I). LV = Left ventricle; RV = right ventricle, red scale bars = 0.5 mm.

Copyright

This image is from Kim BJ, PLoS One 2013;8(2):e57460, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199403

Associated Alleles

Symbol	Name
Rere^eyes3	arginine glutamic acid dipeptide (RE) repeats; eyes 3
Rere^om	arginine glutamic acid dipeptide (RE) repeats; openmind

Associated Genotypes

Allelic Composition	Genetic Background
Rere^eyes3/Rere^om	B6.Cg-Rere^eyes3/Rere^om