Phenotype Image Detail

Image

Caption

(H, I) Ruffled endoderm in the posterior of the yolk sac (arrowhead) of Ctdnep1^tm1Ryn/Ctdnep1^tm1Ryn (Dullard^-/-) embryos at (H) E7.5 late streak to early bud stage and (I) E7.75 late bud to head fold stage. (J) Sagittal sections of E7.75 homozygous (Dullard^-/-) mutant and (K) heterozygous (Dullard ^+/-) embryos. Homozygous mutant embryos did not form the allantois or amniotic fold (arrowhead). (L) E8.25 homozygous embryo showing retarded development compared with that of a (M) heterozygous littermate. (N) Sagittal sections of an E8.25 homozygous embryo showing poor development of extraembryonic structures (allantoic bud, yolk sac, and amnion; arrowheads) and the embryo proper compared with those in (O) heterozygous embryos. (P) E9.5 homozygous embryo (left) showing arrested development compared with that of a heterozygous embryo (right). Scale bars = 100 um (H-O) and 200 um (P).

Copyright

This image is from Tanaka SS, PLoS One 2013;8(3):e57428, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199855

Associated Alleles

Symbol	Name
Ctdnep1^tm1Ryn	CTD nuclear envelope phosphatase 1; targeted mutation 1, Ryuichi Nishinakamura

Associated Genotypes

Allelic Composition	Genetic Background
Ctdnep1^tm1Ryn/Ctdnep1^tm1Ryn	involves: 129P2/OlaHsd * C57BL/6