Phenotype Image Detail

Image

Caption

Lens induction failure in Pax6^{tm2(Pax6_i5a,Pax2)Xzh}/Pax6^{tm2(Pax6_i5a,Pax2)Xzh} (Pax6^5a/5a) and Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh}/Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh} (Pax6^Pax2/Pax2) knock-in mutants. A-C, no obvious eye structure was observed in the E15.5 mutants (arrows).

Copyright

This image is from Carbe C, J Biol Chem 2013 Apr 26;288(17):12130-41 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198381

Associated Alleles

Symbol	Name
Pax6^tm2.1(Pax6_i5a,Pax2)Xzh	paired box 6; targeted mutation 2.1, Xin Zhang
Pax6^tm2(Pax6_i5a,Pax2)Xzh	paired box 6; targeted mutation 2, Xin Zhang

Associated Genotypes

Allelic Composition	Genetic Background
Pax6^tm2(Pax6_i5a,Pax2)Xzh/Pax6^tm2(Pax6_i5a,Pax2)Xzh	involves: 129S6/SvEvTac
Pax6^tm2.1(Pax6_i5a,Pax2)Xzh/Pax6^tm2.1(Pax6_i5a,Pax2)Xzh	involves: 129S6/SvEvTac * C57BL/6 * FVB/N