Phenotype Image Detail

Image

Caption

Defective retinal development in Pax6^{tm2(Pax6_i5a,Pax2)Xzh}/Pax6^{tm2(Pax6_i5a,Pax2)Xzh} (Pax6^5a/5a) and Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh}/mgi:5512912 (Pax6^Pax2/Pax2) mutants. A-B", Pax6(5a) and Pax2 were expressed in the residual Pax6 mutant optic vesicles (arrowhead). nr, neural retina; le, lens; os, optic stalk; od, optic disc. C-D", entire mutant optic vesicles (dashed lines) expressed neural retinal marker Sox2 but not retinal pigmented epithelium marker Mitf. E-J", the retinal differentiation factors Ptf1a, Brn3a, NF165, Islet1, and VC1.1 were lost in the mutant optic vesicles (dashed lines), but photoreceptor cell differentiation gene Crx was ectopically expressed (arrows). Scale bar, 100 um.

Copyright

This image is from Carbe C, J Biol Chem 2013 Apr 26;288(17):12130-41 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:198381

Associated Alleles

Symbol	Name
Pax6^tm2.1(Pax6_i5a,Pax2)Xzh	paired box 6; targeted mutation 2.1, Xin Zhang
Pax6^tm2(Pax6_i5a,Pax2)Xzh	paired box 6; targeted mutation 2, Xin Zhang

Associated Genotypes

Allelic Composition	Genetic Background
Pax6^tm2(Pax6_i5a,Pax2)Xzh/Pax6^tm2(Pax6_i5a,Pax2)Xzh	involves: 129S6/SvEvTac
Pax6^tm2.1(Pax6_i5a,Pax2)Xzh/Pax6^tm2.1(Pax6_i5a,Pax2)Xzh	involves: 129S6/SvEvTac * C57BL/6 * FVB/N