Phenotype Image Detail

Image

Caption

Progressive deterioration in cerebrum, cerebellum and spinal cord of Ei24^tm1Hzha/Ei24^tm1Hzha Tg(Nes-cre)1Kln/0 (Nes Ei24^f/f) mice. A, NissI staining of the cortex in control and mutant mice at different ages shows progressive accumulation of vacuolated cells. Bar, 100 um. B and C, number of Purkinje cells (B) and the thickness of the molecular layer (C) in cerebella from mutant mice at different ages. D, co-staining of Beta-tubulin III (green) and p62 (red) in cerebrum shows that axonal fibers become progressively more irregularly arranged. p62 aggregates and diffuse levels of p62 in mutants also become dramatically elevated with age. Bar, 10 um. E, axon terminals of Purkinje cells in the deep cerebellar nuclei (DCN) region, stained by anti-calbindin, become progressively more dilated. Bar, 10 um.

Copyright

This image is from Zhao YG, J Biol Chem 2012 Dec 7;287(50):42053-63 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:193420

Associated Alleles

Symbol	Name
Ei24^tm1Hzha	etoposide induced 2.4 mRNA; targeted mutation 1, Hong Zhang
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Ei24^tm1Hzha/Ei24^tm1Hzha Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL