Phenotype Image Detail

Image

Caption

5C, H&E-stained liver sections from control (Alb Ei24^f/+) and Ei24^tm1Hzha/Ei24^tm1Hzha Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 (Alb Ei24^f/f) mutant mice show disorganized hepatic lobules and swollen hepatocytes. Insets show higher magnification views. Bar, 50 um. D, gross anatomy of livers from mutant mice at 10 months of age demonstrates the development of multiple tumor-like protrusions (arrows). E, H&E staining of liver sections from mutant mice at 10 months ofage (first panel). The arrow indicates a tumor-like protrusion. Bar, 100 um. Higher magnification images of livers from controls (second panel) and Ei24-deficient mice (third panel, protrusion region) at 10 months of age. Bar, 20 um.

Copyright

This image is from Zhao YG, J Biol Chem 2012 Dec 7;287(50):42053-63 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:193420

Associated Alleles

Symbol	Name
Ei24^tm1Hzha	etoposide induced 2.4 mRNA; targeted mutation 1, Hong Zhang
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson

Associated Genotypes

Allelic Composition	Genetic Background
Ei24^tm1Hzha/Ei24^tm1Hzha Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA