Phenotype Image Detail

Image

Caption

Ovulation impairment in gonadotropin treated Pgr^tm4.2Lyd/Pgr^tm4.2Lyd (PR^d/d) and Pgr^tm1Bwo/Pgr^tm1Bwo (PRKO) mice. (a) Table summarizes the average number of oocytes (+/- SEM) retrieved per mouse following gonadotropin treatment. Note that the wild-type (WT) ovary yields a significant number of oocytes, whereas oocytes are absent from the similarly treated Pgr^tm1Bwo/Pgr^tm1Bwo (PRKO) and PR^d/d ovary. (b) Representative section (stained with H&E) of a WT ovary following gonadotropin treatment. Note the absence of intraovarian oocytes but the presence of a corpus luteum (CL). (c) and (d) show representative sections of an ovary derived from similarly treated PRKO and PR^d/d mice, respectively. Arrowhead indicates the position of an entrapped oocyte within CLs in both sections. Scale bar in (b) applies to (c) and (d) (N = 5 per genotype).

Copyright

This image is from Fernandez-Valdivia R, Genesis 2010 Feb;48(2):106-13, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:158406

Associated Alleles

Symbol	Name
Pgr^tm1Bwo	progesterone receptor; targeted mutation 1, Bert W O'Malley
Pgr^tm4.2Lyd	progesterone receptor; targeted mutation 4.2, John P Lydon

Associated Genotypes

Allelic Composition	Genetic Background
Pgr^tm1Bwo/Pgr^tm1Bwo	involves: 129S7/SvEvBrd
Pgr^tm4.2Lyd/Pgr^tm4.2Lyd	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N