Phenotype Image Detail

Image

Caption

Phenotype of Sp2^tm1.2Sus/Sp2^tm1.2Sus (Sp2null) embryos. A) A Sp2null embryo at E9.5 in comparison to wild-type (Sp2wt) and heterozygous (Sp2+/-) littermates. B) An Sp2null embryo at E9.5 in direct comparison to an E8.5 Sp2wt embryo. C) Serial longitudinal sections of heterozygous Sp2 (Sp2+/-) and Sp2null embryos from day E9.0. Sp2null embryos are smaller, have not turned and have an open cranial neural tube (Nt). Ne, neural epithelium.

Copyright

This image is from Baur F, PLoS One 2010;5(3):e9587, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158671

Associated Alleles

Symbol	Name
Sp2^tm1.2Sus	Sp2 transcription factor; targeted mutation 1.2, Guntram Suske

Associated Genotypes

Allelic Composition	Genetic Background
Sp2^tm1.2Sus/Sp2^tm1.2Sus	involves: 129P2/OlaHsd * C57BL/6