Phenotype Image Detail

Image

Caption

Abnormal gross appearance and histology of Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 (+/P253R) mice. A-D) Alizarin red S and Alcian blue staining of the skull shows domed-shaped skulls with shortened anterioposterior length, short nasal snouts and upper jaw in mutant; I,J) Alizarin red S and Alcian blue staining of the chest shows abnormal bony fusion of sternum (white arrow) in mutant. E-H) Palate abnormalities: (E, F) Superior view shows a defect located at the junction between the primary and secondary palate in mutant (arrow). (G, H) Histology shows incomplete fusion in mutant (arrows). (K, L) Abnormal chondro-osseous transition at the physis in mutant (brackets). Panels A, C, E, G, I, and K are from littermate controls. Panels B, D, F, H, J, and L are the corresponding organs and tissues in mutant mice. (Scale bars: I-P = 50 um).

Copyright

This image is from Wang Y, BMC Dev Biol 2010;10():22, an open-access article, licensee BioMed Central Ltd. J:158773

Associated Alleles

Symbol	Name
Fgfr2^tm2Ewj	fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm2Ewj/Fgfr2^+ Tg(EIIa-cre)C5379Lmgd/0	B6.Cg-Fgfr2^tm2Ewj Tg(EIIa-cre)C5379Lmgd