Phenotype Image Detail

Image

Caption

Micro-CT of the skulls of Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 (+/P253R) mice and wild-type (WT) littermates. A-D) Mutant skull is shorter in the rostro-caudal, maxilla, and mandible lengths than those of the WT controls. In the mutants, the zygomatic process of the maxilla and the malar bone are fused (B, D; white arrows) and unilateral or bilateral coronal synostosis occurs (B, D; black arrows). E, F) The developing mutant palates are shorter than theWT. In the mutants, the inter-premaxillary suture is patent (F; white arrow) with fusion of the premaxilla-maxillary sutures (F; black arrow). The suture between the horizontal plate of the palatine bone and palatal process of the maxilla is patent in themutant and WT (F; red arrow). The midline suture between the palatal shelves of the maxilla are patent in mutant mice as well as in some controls (F; blue arrow). Portions of the maxilla were darkened in Photoshop to allow observation of the fusion of the zygomatic process. Panels A, C, and E are from littermate controls. Panels B, D, and F are from mutant mice.

Copyright

This image is from Wang Y, BMC Dev Biol 2010;10():22, an open-access article, licensee BioMed Central Ltd. J:158773

Associated Alleles

Symbol	Name
Fgfr2^tm2Ewj	fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm2Ewj/Fgfr2^+ Tg(EIIa-cre)C5379Lmgd/0	B6.Cg-Fgfr2^tm2Ewj Tg(EIIa-cre)C5379Lmgd