Phenotype Image Detail

Image

Caption

Histological analysis of the abnormal calvarial sutures in Fgfr2^tm2Ewj/Fgfr2⁺ Tg(EIIa-cre)C5379Lmgd/0 (+/P253R) mice. A-D) HE staining shows the abnormal development of the mutant coronal suture from P0 to P5 with presynostosis, disorganization of cells between the osteogenic fronts and osteoid deposition at P0 (A, B); and synostosis at P5 (C, D). E-H) HE staining shows the abnormal development of the mutant lambdoid (E, F) and sagittal suture (G, H) with proximate osteogenic fronts and cellular disorganization at P0. I, J) abnormal cartilage at the sagittal suture (blue arrows). Panels A, C, E, G and I are from littermate controls. Panels B, D, F, H and J are the corresponding regions in mutant mice. Black arrows, osteogenic fronts; arrowheads, presynostosis/synostosis. (Scale bars: A-D = 25 um; E-J = 50 um.

Copyright

This image is from Wang Y, BMC Dev Biol 2010;10():22, an open-access article, licensee BioMed Central Ltd. J:158773

Associated Alleles

Symbol	Name
Fgfr2^tm2Ewj	fibroblast growth factor receptor 2; targeted mutation 2, Ethylin Wang Jabs
Tg(EIIa-cre)C5379Lmgd	transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm2Ewj/Fgfr2^+ Tg(EIIa-cre)C5379Lmgd/0	B6.Cg-Fgfr2^tm2Ewj Tg(EIIa-cre)C5379Lmgd